The role of nitric oxide in the body

Nitric oxide is a natural gas that is produced in the endothelial cells of blood vessels. Its production takes place through an enzymatic pathway from the amino acid L-arginine. It is produced by an enzyme called nitric oxide synthase (NOS). This process ensures the relaxation of smooth muscle in blood vessels, leading to vasodilation - expansion of blood vessels.

NO affects a number of processes, including the regulation of blood pressure and the prevention of platelet aggregation. It is also involved in the protection of endothelial cells from oxidative stress, which is crucial in the prevention of atherosclerosis.

Nitric oxide plays a vital role in promoting sexual health because it promotes blood flow to the genitals. Its deficiency is often associated with erectile dysfunction. Increased NO production improves blood vessel dilation and promotes healthy erection.

It also helps to reduce the feeling of fatigue by improving the transfer of oxygen and nutrients to the cells. This has an effect on energy metabolism and the body's ability to regenerate after physical and mental stress.

NO promotes higher athletic performance by optimizing blood flow to the muscles and improving oxygen utilization. Athletes often report increased endurance and improved recovery due to dietary supplements aimed at stimulating NO. Improved microcirculation has a positive effect on healing tissue and reducing the risk of muscle injury. In addition, nitric oxide helps to support the immune response by improving the transport of white blood cells to sites of inflammation.

In the long term, regular NO support may help to prevent neurodegenerative diseases because it improves blood flow through the brain. The combination of these factors makes NO a molecule with multiple positive effects on human health and performance.

Cardiovascular benefits

One of the main benefits of nitric oxide is its ability to improve blood flow. Endothelial dysfunction, where blood vessels lose their ability to respond optimally to pressure changes, is the initial step to a number of cardiovascular diseases. Promoting NO production helps to eliminate this dysfunction and restore healthy blood vessel function.

Regular production of nitric oxide has a positive effect on:

• Blood pressure regulation.
• Improving blood circulation in peripheral tissues.
• Reducing the risk of thrombosis.
• Protecting against oxidative stress that damages blood vessels.

According to a study published in the journal Circulation Research, NO improves endothelial function, leading to a reduced risk of heart attacks and strokes. Research also suggests that improved endothelial function due to NO is essential in preventing hypertension and atherosclerosis.

NO production in the body

The production of NO decreases with age. In adults over 40 years of age, its level is reduced by up to 50%. This decline is associated with a greater risk of hypertension and other cardiovascular diseases. Increasing NO production can be achieved through a combination of a healthy diet, exercise and specific dietary supplements.

How to boost nitric oxide production

The basic building block is arginine, which is found in foods such as nuts, seeds, fresh fish and legumes. Another important ingredient is citrulline, which increases the level of arginine in the body. Nitrates found in leafy greens like spinach and beetroot are another way to stimulate NO production.

Regular physical activity promotes the enzyme NOS, which facilitates NO synthesis. It also has a beneficial effect on the health of blood vessel walls.

Supplementation aimed at promoting NO is another effective step. Products containing the amino acids arginine, citrulline and ornithine contribute to the efficient synthesis of this molecule. Regular use of dietary supplements targeting nitric oxide is desirable and provides long-term benefits.

Impact on athletic performance

Nitric oxide improves the delivery of oxygen and nutrients to muscles, which has a positive effect on athletic performance. Athletes who supplement NO through diet or supplements experience increased endurance and shorter recovery times.

According to a meta-analysis published in the Journal of Applied Physiology, NO supplementation results in improvements in the maximum amount of oxygen the body can use during intense exercise (VO2 max) and overall exercise capacity. This proves that NO plays a key role not only in health but also in athletic performance.

Specialist interest on blood circulation

Expert publications on nitric oxide yield fascinating results. For example, research in the journal Hypertension has shown that NO plays a key role in relaxing blood vessels and regulating blood pressure. Studies also highlight its importance in the treatment** of coronary disease **heart disease and heart failure.

Of further interest is research published in The Lancet that has shown that increasing NO levels through a nitrate-rich diet leads to improved vascular elasticity and lower blood pressure in patients with hypertension. The importance of nitric oxide has also been highlighted in the context of preventing type 2 diabetes mellitus, where it plays a role in protecting against inflammation and oxidative stress.

OXINO as a modern solution

Dietary supplements aimed at promoting nitric oxide production, such as OXINO, are an effective solution for anyone looking to improve their cardiovascular health. They contain the ideal combination of arginine, citrulline and ornithine, which synergistically support optimal NO production. Other active ingredients are the patented VinitroxTM and S7®blend containing natural antioxidants. These may increase the availability of NO and protect it from rapid degradation. These supplements not only support vascular health, but also improve athletic performance and accelerate recovery after physical exertion.

Regular supplementation is safe and can have long-term beneficial effects on health.

Conclusion

Nitric oxide is an indispensable molecule for the health of our cardiovascular system. Its role in regulating blood pressure, protecting blood vessels and improving blood circulation is unquestionable. Promoting its production through diet, exercise and modern dietary supplements such as Oxino is the key to preventing many diseases of civilization.

Sources:

• Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987). Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proceedings of the National Academy of Sciences, 84(24), 9265-9269.
• Moncada, S., & Higgs, A. (1993). The L-arginine-nitric oxide pathway. The New England Journal of Medicine, 329(27), 2002-2012.
• Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007). Effects of dietary nitrate on oxygen cost during exercise. Acta Physiologica, 191(1), 59-66.
• Ghosh, S. M., Kapil, V., Fuentes-Calvo, I., Bubb, K. J., Pearl, V., Milsom, A. B., & Ahluwalia, A. (2013). Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential. Hypertension, 61(5), 1091-1102.