Nitric oxide and its function

Nitric oxide (NO) is a fascinating molecule that plays a key role in many important processes in the human body. It acts as a vasodilator, meaning that it dilates blood vessels to facilitate blood flow. It has many positive effects, including:

• Reducing blood pressure - High blood pressure is a serious health problem that can lead to heart attacks, strokes and other complications. Increasing NO production helps to lower blood pressure and thus the risk of these diseases.

• Blood Circulation Support - Proper blood circulation function is essential for delivering oxygen and nutrients to all cells in the body. NO helps to improve blood circulation, thereby supporting the health of the entire body.

• Strengthening the immune system - NO plays an important role in the body's immune defense. It helps fight infections and inflammation.

• Accelerating healing and regeneration - NO promotes the formation of new blood vessels and accelerates the process of regeneration and healing.

• Increased athletic performance - NO helps muscles work more efficiently and longer, increasing athletic performance.

• Improves erectile function - NO is essential for erections. Increasing NO production can improve erections and potency in men.

• Signal molecule - NO functions as a signal molecule in the body. It is able to communicate with cells in the body and transmit the necessary information needed for proper physiological processes.

• Reducing feelings of fatigue - by increasing the production of NO, blood circulation and blood flow is improved. This means that nutrients are able to circulate faster to the necessary places, thus reducing the feeling of fatigue.

Oxino and its composition

Our OXINO range contains quality ingredients that support the body's natural production of NO. The unique ratio of amino acids and patented ingredients is a unique combination. The goal is to maximize the body's natural potential and support the body's natural processes.

Arginine alpha-ketoglutarate

Arginine is one of the semi-essential amino acids and is an important mediator of the ornithine cycle. It is involved in the formation of creatine and nitric oxide.

Arginine alpha-ketoglutarate (AAKG) is a compound that combines the amino acid arginine with alpha-ketoglutarate, an important intermediate in the Krebs cycle (tricarboxylic acid cycle), which is crucial for cellular energy metabolism. In the body, it plays an important role in the metabolism and production of nitric oxide (NO).

L-citrulline

Citrulline malate, which plays a major role in this dietary supplement, is a combination of an amino acid and malic acid. The fact that the amino acid is bound to an organic component (malate) also makes it more absorbable and usable by the body.

L-citrulline is a precursor to arginine, an amino acid that is essential for NO production. Malate in turn supports energy metabolism and the production of ATP, the energy needed for various biochemical processes in the body, including NO synthesis. L-citrulline malate thus supplies both L-citrulline and malate to the body, thereby supporting NO production and energy metabolism.

L-ornithine HCl

L-ornithine hydrochloride (L-ornithine HCl) is a form of the amino acid L-ornithine that is bonded with hydrogen chloride. In the body, it plays an important role in the urea cycle, the ammonia detoxification process, and also in the production of nitric oxide (NO).

L-ornithine is a precursor to arginine, an amino acid that is essential for NO production. L-Ornithine HCl thus delivers L-ornithine to the body, thereby supporting NO production. In addition, L-ornithine HCl can stimulate the activity of the enzyme NO synthase, which is responsible for the conversion of arginine to NO.

S7 Blend

Is a proprietary blend of seven plant extracts that was developed to support nitric oxide (NO) production in the body.

This patented formula contains seven phytonutrient-rich plants - green coffee, green tea, turmeric, cherry, blueberry, broccoli and kale extracts. The ingredient contains 60% polyphenols, 30% catechins and 3% curcumin to ensure quality and potency.

This plant complex is a trigger of the body's own nitric oxide production. It significantly reduces oxidative stress, which is confirmed through scientific studies. People who have consumed S7 Blend have demonstrated increased concentrations of bioactive nitric oxide, reduced oxidative stress and improved cellular function.

Vinitrox

Is a patented ingredient that is designed specifically for active people seeking natural dietary supplements to enhance performance. It is a unique combination of polyphenols from apples and grapes that offers a variety of health-promoting benefits.

Vinitrox is a science-based ingredient that offers significant benefits by increasing nitric oxide production, improving blood flow and reducing muscle fatigue. This makes it a valuable addition for sports nutrition products and health support supplements.

Vitamin C

Also known as ascorbic acid, is a water-soluble vitamin and a powerful antioxidant. It plays a key role in many biochemical processes in the body, including collagen synthesis, iron absorption, strengthening the immune system and protecting cells from oxidative stress.

Vitamin C plays an important role in supporting the production of nitric oxide, protecting it from degradation and supporting the enzymatic processes that lead to the synthesis of NO from arginine, citrulline and ornithine. In this way, it contributes to better blood flow, improved vascular function and overall cardiovascular health.

Magnesium Citrate

This is a chelated form of magnesium. It is one of the most absorbable forms of magnesium, often used as a dietary supplement to increase magnesium levels in the body.

Magnesium citrate is a highly absorbable form of magnesium that supports a number of biochemical processes in the body, including muscle and nerve function, metabolism and bone health. It can also support NO production by activating nitric oxide synthase and protecting NO from oxidation. In conjunction with L-citrulline, it may improve the effectiveness of this amino acid in increasing NO levels.

Sources:

• Gonzalez AM, Trexler ET. Effects of Citrulline Supplementation on Exercise Performance in Humans: A Review of the Current Literature. J Strength Cond Res. 2020 May;34(5):1480-1495. doi: 10.1519/JSC.0000000000003426. PMID: 31977835.
• Gesbert F, Garbay C, Bertoglio J. Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells. J Biol Chem. 1998 Feb 13;273(7):3986-93. doi: 10.1074/jbc.273.7.3986. PMID: 9461587.
• ALLERTON, T., PROCTOR, D., STEPHENS, J., DUGAS, T., SPIELMANN G., IRVING, B. L-Citrulline Supplementation: Impact on Cardiometabolic Health. Nutrients [online]. 2018, 10(7) [cited 2021-7-13]. ISSN 2072-6643. Available from: doi:10.3390/nu1007092
• HNÍZDOVÁ, I. - LUHOVÁ, L. - PETŘIVALSKÝ, M. Protein Nitration by Reactive Nitrogen Species. Chemické Listy, 2009, vol.103, no.10, pp.788-794.
• MARUNA, P. Nitric oxide in hypothalamo-pituitary regulation - I. Physiology. Clinical Biochemistry and Metabolism, 2006, no.4, pp.189-193
• BAILEY, S.J., BLACKWELL, J.R., LORD, T., VANHATALO, A., WINYARD, P.G., JONES, A.M. l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. J Appl Physiol (1985). 2015 Aug 15;119(4):385-95. doi: 10.1152/japplphysiol.00192.2014. Epub 2015 May 28. PMID: 26023227.
• CORMIO, L., DE SIATI, M., LORUSSO, F., SELVAGGIO, O., MIRABELLA, L., SANGUEDOLCE, F., CARRIERI, G. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. 2011 Jan;77(1):119-22. doi: 10.1016/j.urology. 2010.08.028. PMID: 21195829.